Boston London New York

Subscribe by Email

Your email:

Current Articles | RSS Feed RSS Feed

A New Biotech Funding Model is Critical to Survival of the Industry?

  
  
  
  

Posted by Richard Gabriel on Thursday, March 25, 2010 @ 2:00PM

By Richard Gabriel

So what's wrong with Biotech financing today? What will it take to bring the Biotech market out of the doldrums and back into action? If you are having trouble finding financing for your next greatest idea then the only comforting news is that you are not alone.

Venture capital technology assessments, which are advisory diagnostics we perform frequently, have revealed some interesting information. Unfortunately, when the biotech bubble first burst, right around the 9-11 time period, there were already a bunch of troubled venture capital funds. Most of these funds became challenged because the time horizon for their investment to mature is too short for the drug development cycle. Too many of these firms believed that the capital market was an exit strategy.  True, for some it was the best thing to do, and to a point it made sense for both company and investor - but not today. Following the market collapse and then the near fatal blow that the biotech market received along with the rest of the market, venture capital in the bio tech sector was and continues to be in a state of disarray. There are, however, a few funds that actually know how to make money in the biotech world.  The problem is they too are having trouble raising capital for their next funds. Overall the VC market is a nightmare for biotech with lots of rationalization expressed - too early, too late, not enough differentiation, to expensive, too long to market.  When all boiled down it shapes up as too many people that don't know how to develop a drug controlling the capital to one of America's brightest economic and social stars - medicine.

The trend for finding later stage products is so rapacious right now that VC funds are having deal flow problems. Everyone wants to jump on the band wagon, leaving the start up holding the ‘your too early for us' bag of hot air. Ask Pfizer what they think of late stage drug investment? They just dropped $215MM on a drug from Russia that showed great clinical efficacy in Alzheimer's patients in Russia and the surrounding areas and has been in use for over 10 years, and guess what? Bring it to the U.S. for clinical trials and it shows absolutely NO clinical efficacy against the placebo! Who said late stage drug development was lower risk? Somebody tell the Pfizer board.

For $215MM and some savvy investment types, Pfizer management could have invested in 10 start-up's at $5.0MM a pop and reserved $15MM each as the investments hit their milestones. Now granted the chances of a drug start up reaching the market is pretty low, but come on folks, $215MM will buy you a lot of entrepreneurial grease, commitment and energy as well as some damn good technology. In my book, I like the odds of the new technology over slumping something just because it is in Phase 2 clinical trials or worse as Pfizer found out. So much for due diligence. But why take the chance and invest in the ‘too early' crowd of drugs and technologies?

The new drugs being developed today are smarter because they will be tied to diagnostics to help physicians decide who should get the drug and who shouldn't. This new combination technology approach to drug approval could be a decidedly better approach to drug development then what most investors are doing today with their ‘closer to market' picks. Why is that the case? The FDA likes this approach, tie a diagnostic to a drug, prove the efficacy, and your going to get approved!

The long and the short of it is that in the biotech world the ‘valley of death' extends from Boston to San Diego and swings up to San Francisco and bounces its way across the globe to the Far East, Europe and the UK. The only people who seem to be getting all the money are the people in India, China and other places that are trying to eat the pharmaceutical and biotech industries' lunch in Europe and the U.S. with generics, biogenerics and more cut rate manufacturing suites than you can shake a stick at. Nothing wrong with that but hardly any one is paying attention to new technology.

Isn't it time we looked for a better financing model for Biotech products? We think so. Got any ideas? Let us know what you think might be a better way to fund Biotech!

                         ___________________________________________

Richard Gabriel is head of the Life Science practice at Sema4 Inc., dba Semaphore (http://www.sema4usa.com/), a leading global professional services provider of Private Equity funds-under-management and technology diligence services. Semaphore currently holds fiduciary obligations as General Partner for six Private Equity and Venture Capital funds and advises General and Limited Partners as well as Corporations around the world. Semaphore's corporate offices are in Boston with principal offices in New York and London.


Comments

"Got any ideas? 
 
Yup. One anyway. It's been described to me by more than one investor as "the Hollywood model". The big studios provide the facilities. Some are in-house, but mostly they are outsourced. The idea for the film is taken up by the Producer who assembles the film project and raises the money. A vehicle is put together for the life-time of the film, dispenses the costs to the facilities, the crew and the talent. The film studios and crew get paid to complete the project and they and the big talent get some mix of payment and equity stake. The vehicle owns the IP and other commercial rights and disburses the rewards to the shareholders (studio, talent and investors) at the end of the project. The advantage to the investors is that their money goes directly into the product, not into setting up the studios and the capital needed for the bricks and mortar, equipment and hiring the operational management. At the end of the project the investors have no liabilities for any of the studio costs, people or depreciation. They just disburse any profits, close down the vehicle and move on to the other projects in their investment portfolio. 
 
So it seems to me that this is the basis for a new Biotech business model. It would have the same advantage to the investors that they are not splashing cash on facilities and highly paid management, but directly on a drug project or portfolio of projects. They can assess progress by best practice project and portfolio management and switch on or off funding depending on progress. This is a new and exciting opportunity for the talent, which in our Biotech world are the experienced drug hunters, many of whom have recently been paid off by Pharma and have time on their hands. In the Hollywood model, they get rewarded through a stake in the project's success and they get to work in a small focussed team of like minded experts to deliver the project, not struggle waste their lives fighting through corporate undergrowth. The producer role is a fascinating one. Those entrepreneurial scientists that can pull a project together and raise the money. Not like now, when one start-up company costs 5-10 years of an entrepreneurial scientist's career - but for multiple projects with a 1-2 year lifespan. If I was a Biotech investor, I'd be hiring Producers.  
 
So I'd expect this model would give low start up costs, near zero fixed operational costs, high scalability and much more flexibility to start and finish projects depending on success. 
 
The talent is there, many of whom could be Producer's. CRO's provide the outsourced lab and other capital-intensive facilities for chemistry, screening, DMPK etc, but there remains a gap in the market for the "Hollywood Studios of Biotech" that would make all this work in practice. 
 
Hope this makes sense and welcome any discussion. 
 
David E Leahy 
CEO Molplex
Posted @ Monday, January 31, 2011 8:10 AM by David E Leahy
David, we have created a non-profit 'Hollywood Studio of Biotech' to be even more cost effective.
Posted @ Wednesday, May 04, 2011 4:02 PM by John Didsbury
Brilliant work ! Your web page has provided me much of the strategies I needed . Santa Ana CA Locksmith Locksmiths in Norwalk Hayward locksmith Locksmith Sunnyvale plano tx locksmith aventura locksmith locksmith hialeah Locksmith Atlanta GA Atlanta Locksmiths Memphis Locksmith Locksmith Memphis TN Washington Locksmiths Memphis Locksmith Locksmith Atlanta Memphis Locksmith Locksmith Memphis TN Corona CA Locksmith Hampton Locksmith Hampton Locksmith Locksmith Corona CA Hampton Locksmiths Locksmith Corona Corona Locksmith Locksmith Hampton Carrollton Locksmith Plumbing Garden Grove FL Locksmith Auburn WA Locksmith Aspen Hill MD Locksmith Arcadia CA Locksmith Atlanta Locksmith Memphis Locksmith Opa locka Locksmith Boca Raton Locksmith Deerfield Beach FL Locksmith Davie Locksmiths Coral Gables Locksmiths Gilbert Jupiter Locksmiths Locksmiths Richardson norwalk Locksmiths Locksmiths Auburn Locksmiths Haddon Township Locksmiths Elizabeth Locksmith Garfield Locksmith in Plantation Locksmith Elizabeth Locksmith Mt Vernon Locksmith Chicago Locksmith Arcadia Locksmith in Livonia Locksmith in Henderson Locksmith Long Beach CA Dallas TX Locksmith Detroit Locksmith Indianapolis IN Locksmith Houston Locksmith
Posted @ Wednesday, May 25, 2011 10:01 AM by james
Well done. We re amazed with the quality of the details offered. I hope that you keep up with the brilliant job achieved. 
 
Riverside Locksmith 
 
Plantation locksmiths 
 
Locksmith Alameda CA 
 
Locksmith Mountain View 
 
locksmith plano texas 
 
plano locksmith 
 
miami beach locksmith 
 
Atlanta Ga Locksmith 
 
Locksmith Memphis 
 
Memphis Locksmith 
 
Memphis TN Locksmith 
 
Atlanta Locksmith 
 
Memphis TN Locksmith 
 
Locksmith Memphis TN 
 
Locksmith Memphis 
 
Atlanta Ga Locksmith 
 
Locksmith Hampton 
 
Corona Locksmith 
 
Locksmith Corona 
 
Locksmith Hampton 
 
Locksmith Hampton 
 
Hampton Locksmith 
 
Hampton Locksmith 
 
Locksmith Hampton VA 
 
Locksmith Pembroke Pines CA 
 
Baltimore Locksmith 
 
Locksmith Corona CA 
 
Locksmith Carson 
 
Locksmith Golden CO 
 
Memphis Locksmith 
 
Locksmith Atlanta GA 
 
Locksmith Kendall 
 
Cliffside Park Locksmith 
 
Locksmith Naperville 
 
Locksmith Chicago 
 
Ontario Locksmiths 
 
Paterson Locksmiths 
 
Rancho Cucamonga Locksmiths 
 
Warren Locksmiths 
 
Locksmiths Reading 
 
norwalk Locksmiths 
 
Corona Locksmiths 
 
Livingston Locksmiths 
 
Locksmith in Ontario 
 
Locksmith Newton 
 
Locksmith in Rancho Cucamonga 
 
Locksmith in Fort Worth 
 
Locksmith Union 
 
Locksmith in Allen 
 
Locksmith in Golden 
 
Locksmith in Livonia 
 
Dallas Locksmiths 
 
Indianapolis Locksmiths 
 
Detroit Locksmith 
 
Locksmith Long Beach CA 
 
Locksmith Houston TX 
 
Posted @ Wednesday, May 25, 2011 10:02 AM by james
Done well. I am astounded with the standard of the advice presented. I sincerely hope that you keep up with the outstanding job succesfully done. locksmith in fort lauderdale Bayonne Locksmiths Locksmith Hayward Locksmith RedwoodCity CA irvine ca locksmith locksmith plano tx locksmith aventura fl Memphis Locksmith Locksmith Memphis TN Memphis Locksmith Atlanta Locksmiths Atlanta Ga Locksmith Memphis TN Locksmith Locksmith Memphis Atlanta Locksmiths Locksmith Memphis Corona Locksmith Corona Locksmith Locksmith Corona Corona Locksmith Hampton Locksmith Locksmith Corona CA Locksmith Corona CA Locksmith Corona CA Hollywood FL Plumbing Hialeah Locksmith Locksmith Alhambra Locksmith Westfield Locksmith Milford Memphis TN Locksmith Memphis Locksmith Locksmith North Miami FL Locksmith Wellington FL Richardson Locksmith Lake Worth Locksmith Belleville Locksmiths Locksmiths Bowie Locksmiths Carson Locksmiths Arcadia Locksmiths norwalk Richardson Locksmiths Paterson Locksmiths Locksmiths Bayonne Locksmith Lodi Locksmith in Ann Arbor Locksmith in Bowie Locksmith Henderson Locksmith Allen Locksmith in Garfield Locksmith Hampton Locksmith Bayonne Houston Locksmiths Indianapolis Locksmith Long Beach Locksmiths Detroit Locksmiths Dallas Locksmith
Posted @ Wednesday, May 25, 2011 10:10 AM by james
Your blog posts looks unique and informative. Thanks for sharing this.
Posted @ Friday, July 08, 2011 8:54 AM by Acai Berry Scam
Blue sky is the New Moncler Jackets sun is sweet after hard, New Moncler Coats failed on when Moncler Online Store experience success is brilliant. Not the Discount Moncler ability to turn the last Moncler Down Jackets Men page, turn over the dirt will be lost http://www.moncler-officialwebsite.com/ eyes.
Posted @ Friday, July 29, 2011 7:24 PM by New Moncler Jackets
The mont blanc wallets in my favorite of the gold collection because I have a new prada wallets that would match nicely. 
 
doudoune moncler pas cher sont vraiment lisse quand vous vous sentez et ce contact et c'est la raison pour laquelle les femmes de tous ages qui aiment acheter ces vestes. Les caractères les initiales de l'Clermont monoester de rendre la marque moncler vente à la fin. Le père Moncler particulier - Ramillon commencé à développer des doudoune femme moncler de tous ages par des skis grands et aussi des tentes en 1950. Il aime sa patrie et les montagnes tellement. Alors que la Seconde Guerre mondiale moncler enfants, le résultat direct d'en faire le duratif forte fournis aux armées fran?aises alpines.
Posted @ Friday, August 12, 2011 2:54 AM by handbags
http://www.uggoption.com 
 
 
 
Free shipping uggs 
 
Ads by GoogleEven an ideal offer apart in Australia, cozy from sheepskin Ugg boots, now everywhere, When speaking about women's boots, specifically Ugg boots, you can use a pair of Hunter Willies for muddy, sunny, and water-resistant boots for the reason that Aussies critically adore enjoying the heat by means of the sunshine at an all-purpose pair of women's boots, not merely women's boots. If not yet, then start looking no farther in comparison to women's boots inside the world. 
 
 
 
 
 
Posted @ Friday, August 26, 2011 3:19 AM by Free shipping uggs
Interesting articles are published here. By reading it I acquired great deal of knowledge on various subject. Thank you for sharing with us.
Posted @ Sunday, August 28, 2011 11:43 PM by Outcall Tantric Massage
日本のデザイナーは1997年に創設するブランドMiharayashuhiro近日も長靴の新作ナイキ スニーカーを発表しました。この長靴の品物はブランドの流行する理念と厳格な高さの本質的な仕事に続いて、ジョーダンシューズ靴の身は高級なセーム革などの多種の材質を使って、黒いダイダイとのは色を合わせて持ちつ持たれつで更によくなって、1回のシンプルな休む風格ナイキ バスケ シューズのを製造しだして同時に更に活発な息を添加しました。細部の上で技量に足りたことをするので、調節可の輪は長靴シューズ 通販を最大限度にあなたと両が十分に似合うことができることを掛けます
Posted @ Thursday, September 29, 2011 7:26 PM by ニューバランス スニーカー
bear that you will be stand out <strong>moncler outlet usa</strong> among the crowd.Want to see more style ugg boots,please go to our website girluggboots.com,t <strong>discount uggs</strong> here we wiil give you a new fresh of 2009 newst ugg boots.alice | 20 November 2009 UGG boots <strong>ugg boots for sale</strong> ugg discount ugg boots sale ugg cardyRita | 21 November 2009 ugg classic tall boots <strong>cheap uggs</strong> though you occur to be at the moment getting weighed down. <strong>cheap ugg outlet</strong> The standard Cardy Tall, which could possibly be ordered in potentially black, charcoal or cream, <strong>discount ugg boots</strong> has every from the great things about an UGG boots in the very tall, sophisticated design. <strong>doudoune moncler</strong> There unquestionably are a number of distinct tall UGG boots quickly readily available for ladies, <strong>uggs for sale</strong> such as the Classic <strong>uggs cheap</strong> Tall as well as Knightsbridge. <strong>ugg outlet online</strong> The Classic Tall is obtainable in a selection of hues and prints, ranging from floral motifs to daring, <strong>cheap moncler jackets</strong> stable shades. The Knightsbridge is a full length boot having <strong>Ugg Boots Clearance</strong> a zippered front, earning it quick to put the boots on and just take them off on the stop with the day.
Posted @ Tuesday, October 04, 2011 12:11 AM by UGG Canada
mon sujet de conversation avec d’autres personnes Nike Air Max 24-7enfant n’est pas plus largement? Le problème est que la confiance ou de parler à ces chose très commune aussi longtemps que le fondre dans un amour qui sorte de l’amour divin, ils sont très bon et ce qui est cohérent? Nike Air Max TN.j’ai vu le piano Albertina assis en face de sa carte sont allés automatiquement, ses cheveux sombre, les joues rougeatres: même si elle a voulu ouvrir mes lèvres, mes lèvres semblent se sentir sa langue, sa maternité, et tonique qui ne peuvent manger de la langue sainte, même si c’est seulement pour son Albertina langue doucement brossé mon cou, ma poitrine, sa langue sur la flamme et la rosée mystérieuse aussi causer Je pense que caresse la surface de sa peau de la profonde, profonde a révélé qu’il tire comme un morceau de tissu au fond, de sorte que caresse la surface de même le plus touchant, c’est comme un moyen douce, chaleureuse et mystérieuse. Je ne peux pas dire que je n’ai jamais perdu cette Air Max Pas Cher enfant chose du passé quand ils ont senti les doux moments de désespoir.
Posted @ Wednesday, October 05, 2011 1:43 AM by Nike Air Max TN
 
日本のデザイナーは1997年に創設するブランドMiharayashuhiro近日も長靴の新作ナイキ スニーカーを発表しました。この長靴の品物はブランドの流行する理念と厳格な高さの本質的な仕事に続いて、ジョーダンシューズ靴の身は高級なセーム革などの多種の材質を使って、黒いダイダイとのは色を合わせて持ちつ持たれつで更によくなって、1回のシンプルな休む風格ナイキ バスケ シューズのを製造しだして同時に更に活発な息を添加しました。細部の上で技量に足りたことをするので、調節可の輪は長靴シューズ 通販を最大限度にあなたと両が十分に似合うことができることを掛けます
Posted @ Wednesday, October 05, 2011 4:46 AM by ネイティブ シューズ
The Air Jordan 11 (XI) Retro Low – White / Zest – Argon Blue were released on August 4, 2007, and retailed for $115. They feature a white leather upper with noticeable patterns of perforations which are vertically aligned into columns. The overlying layer features a grey color scheme, as well blue elephant print, which goes well with the blue inner lining. The clear outsole is always a plus, and features a herringbone traction pattern, which provides great grip and traction on the hardwood. These may not feature patent leather, but they are still very nice, and feature an interesting pattern and colorway. This is our range of products online store, the following: 
Kids Air Jordan 
Air Jordan Retro 6 Kids 
Nike Shoes Wholesale 
Nike dunks for sale 
Nike Dunk High Sale 
Nike Dunk High Womens 
Nike Dunk Low Shoes 
Nike dunk low womens 
nike dunks kids 
Ken Griffey Shoes 
Nike Air Max JR 
Nike Air Max Griffey Fury 
Nike Air Griffey Max GD 2 
Nike Air Griffey Max 1 
Nike Air Griffey Max 2 
nike air max 
Nike Air Max Tailwind  
Nike Air Max Trainer 
Nike Air Max 2011 
Nike Air Max 2011 Mens 
Nike air max 2011 womens 
nike air max 2010 
nike air max 2010 mens 
nike air max 2010 womens 
nike air max 2009 
Nike Air Max 2009 Mens 
Nike Air Max 2009 Womens 
Nike Air Max TN 
Nike air max ltd 
Nike air max 95 
Thank you for your visit, hope you like it! 
 
Posted @ Saturday, October 08, 2011 9:02 PM by cuang
 
On laisse par exemple des pays comme la Guinée-Bissau devenir des narco-Etats où l'on abat le chef des armées et où on torture le chef d'Etat dans une terrible boucherie. Air Max Chaussures.Parallèlement, et heureusement, des gens essaient de penser la difficulté, de ne Longchamp pas cher pas retomber dans des schémas difficiles, de ne pas se poser en victimes de l'Histoire mais veulent être acteurs de cette nécessité de changer, des gens comme Boris Diop et d'autres écrivains philosophes. Nike Air Max Pas Cher.Je pense qu'il existe des pistes pour s'en sortir dignement, en reconstruisant. Nike Air Max Classic BW.Ca m'est venu naturellement. 
Posted @ Sunday, October 09, 2011 9:20 PM by Air Max Pas Cher
Buy NFL Officially Licensed Clinton Portis Jersey. Santana Moss Jersey Body: 100% 5-oz polyester premier mesh body. Sleeves/Yoke: 100% 5-oz polyester premier dazzle. Collar: 100% 8.6-oz polyester rib knit. Donovan McNabb Jersey Inserts: 100% 8.6-oz polyester engineered stripe knit. Screenprinted team wordmarks, logos and sleeve details. Embroidered Green Bay Packers Jerseys Equipment patch sewn onto bottom of front collar or fabric insert. Reebok and A.J.Hawk Jersey Equipment jock tag with alpha sizing and team-specific helmet graphic applied above left hem.Single-layer dyed or screenprinted tackle twill player name and number give the appearance of multiple layers.Reebok logo screenprinted on Miami Dolphins Jerseys each sleeve.Decorated in the team colors,Machine wash cold, hang to dry.
Posted @ Sunday, October 09, 2011 9:21 PM by Tim Tebow Jersey
ナイキエアマックスアップテンポ2 1995ナイキのバスケッミズノ サッカースパイク激安販売トボールシューズは、特にデュークAdidas サッカーシューズ - 通販大学排他的なバスケットボールシューズの発売のため、今それが刻まれた。 時代の典型的な特徴、ユニークな舌、クイックレースシステム、機能のアッパー、ソールボックスのパタプーマ キングーン、 ヒールマックスエア270度の可視性を持つアップテンポ1995年に設計されたナイキエアマックス2は、年間で画期的な構成です。一見トータル90したナイキエアマックスアップテンポな2つの非常にバークリーCB34味で。
Posted @ Sunday, October 09, 2011 9:22 PM by プーマ キング
 
 
Usually, there are two versions of purchasing cheap Ugg Boots for sale that are cheap. One type can consist of high top quality product but at much lower price than the normal rate. For the other hand, you can also get a low good quality product which is still lower in price. If you do a proper research, you can notice decent high-quality at low prices. You need to get in touch together with the right Vendor who is capable of selling the Uggs for a good bargain price. 
 
 
 
Posted @ Wednesday, October 12, 2011 3:32 AM by jinyan
 
 
New Era hats
 
 
Red Bull Hats
 
 
monster energy hats
 
 
New york yankees hats
 
 
MLB hats
 
 
Adjustable hats
 
 
wholesale jerseys
 
 
DC hats
 
 
winter hats
 
 
wool hats
 
 
fur hat
 
 
cheap snapbacks
 
 
scarf sets
 
 
hats scarves
Posted @ Thursday, October 13, 2011 1:14 AM by NEW ERA HATS
The clothing of Canada goose on sale has two characteristics: all the jackets are made by the Canadian on the Canadian land; impeccable quality, absolute guarantee of quality. In Canada Goose's workshop, we can see from the design to the original version of the type set to production, all processes are carried out step by step methodical. First, the machine cut out some shapes from the fabric processing, followed by hand-sewing process. The unique design of Canada goose jacket sale, which in addition to more emphasis on practical and beautiful design, and therefore each piece snow suit jacket to go through the testing temperature and other factors, to achieve the best effect of outdoor wear. Canada Goose brand of high quality also determines the price of the luxury brand for many outdoor sports to people who have to have Canada goose parka sale is a symbol of personal identity.
Posted @ Friday, October 14, 2011 7:40 PM by sale canada goose
アジア杯の上の惨敗は私達を中国のサッカーの立ち後れることがはっきり見えさせて、日本のサッカーはすでにブーツ キッズみごとに世界に向かいました。アジア杯の(以)後で、pumaは日の本文で霊感の2足のサッカーシューズに赤 ブーツ変わることを出しました――PWR-C1.10 TokyoとV1.10 Kanji。PWR-C1.10 Tokyoは東京街頭の文化を霊感にして、下手な字を書く方法は日本語の“東京”の印を白色の靴の表面の上にあります。V1.10 Kanjiの中Kanjiは日本語の“漢字”の意味です。設計者は漢字の“高速”の印を靴の表面の上で、際立っていネイティブ フィッツシモンズるV1.10のスピードは思います。哀れみを誘うのは中国の文化の代表の漢字にするのが意外にも日本の文化の元素にして今回の付けてはいけない設計の霊感の出所になったのなのです。見たところサッカーシューズの領域にもっと多い発言権を持ちたくて、中国のサッカーの後ナイキ バスケ シューズれているレベルは最大の妨害です。
Posted @ Wednesday, October 26, 2011 1:41 AM by ネイティブ フィッツシモンズ
adiPUREとadiZERO最初に考えたのを持って来るために、過去に確かにadidasのサッカーシューズの2つです、そして201シューズ 通販1年から2つの用語はもはや排他的なサッカーのシリーズはありません。 adiPUREとadiZEROのバスケットボールシューズの出現をされているとして、アディダスのテニスのジョーダンシューズ製品ラインもadiPURE PROとadiZEROフェザーは、2つの新しいテニスシューズをオープンしました。カテゴリーは違いますが、nike コート家族の特性が接続されていますが、adiPURE PROは、外観の古典的なシンプルさと性能の全体的なバランスをもたらす、とadiZEROフェザー好調ファミリは、スピード感を持って最も鮮やかに反映さadiZEROなります。靴のファンの可用性の認識のnike ウエア考え方の概念を作成し、唯一の私たちが待って見ることができるようにフルラインの製品ラインを持つこのサッカーシューズなど
Posted @ Thursday, November 03, 2011 4:52 AM by シューズ 通販
アジア杯のジョーダン 通販上の惨敗は私達を中国のサッカーの立ち後れることがはっきり見えさせて、日本のサッカーはすでジョーダン スニーカーにみごとに世界に向かいました。アジア杯の(以)後で、pumaは日の本文で霊感の2足のサッカーシューズに変わることを出しました――PWR-C1.10 TokyoとV1.10 Kanji。PWR-C1.10 Tokyoは東京街頭の文化を霊感にして、下手な字を書く方法は日本語の“東京”の印を白色の靴の表面の上にあります。V1.10 Kanjiの中Kanjiは日本ナイキ ジャケット語の“漢字”の意味です。設計者は漢字の“高速”の印を靴の表面の上で、際立っているV1.10のスピードは思います。哀れみを誘うのは中国の文化の代表の漢字にするのが意外にも日本の文化の元素にして今回の付けてはいけない設計の霊感の出所になったのなのadidas ジャケットです。見たところサッカーシューズの領域にもっと多い発言権を持ちたくて、中国のサッカーの後れているレベルは最大の妨害です。 
 
 
 
Posted @ Thursday, November 03, 2011 4:53 AM by ジョーダン 通販
Nikeのハナイキ バスケ シューズ イエンドのサッカーシューズのシリーズELITEある去年派手な1時、adidasは品質はNIKEに負けませんますが、しかし位置付けの上で風下に降りました。近日、1組のサッカーシューズのスパイナイキ ジョーダンはによってadidasの重いサッカーシューズの王の席に帰る遠大な抱負を暴露しました。adidasはadiPOWER PREDATORが発表することをきっかけにするを、SLシリーズのトップクラスのサッカーシューズ 
 
ナイキ コートの製品を出して、その中はPREDATOR SLとadiPURE SLを含みました。2足の靴はすべてF50を採用しました adiZEROの軽量で大きい底、靴の表面の材質も普通な版と違いナイキ ウエア、大いに重さを軽減しました。さらに加えて再びサッカーシューズの軽量の王冠のF50を奪います adiZERO PRIME,adidasのトップクラスのサッカーのシリーズはすでに準備し出発を待ちました。NIKEとadidasの双雄間もなく引き離す大きい幕。 
 
 
 
Posted @ Friday, November 04, 2011 3:54 AM by ナイキ バスケ シューズ
全国縦断オフラインイベントも実施中 
また、ルーセントハートでは現在、10月29日の大阪を皮切りに、全国縦断オフラインイベントを開催中だ。リネージュ2 RMT廣田氏によると、今回のオフラインイベントのコンセプトは「各地のユーザー同士のコミュニティを強化してもらうこと」だという。 
今回、イベントの終演後には女性プレイヤーのコミュニティ「ルーセントハート女子部」による“女子会”も開催される。RO(ラグナロク)RMT女子部の担当者であるシトラスさんは、女子会を通して「女性同士で仲よしの輪を作っていただき、もっともっとゲームを楽しんでもらいたい」と述べ、今後の女子部に関しても「さらに女性色の強いコンテンツを増やしていきたい」と意気込みを明かした。 
オフラインイベントは今後、名古屋?福岡?仙台?東京の各都市を回る予定となっている。リネージュ2 RMT詳しい日程や参加者の募集は公式サイトで順次行われていくため、アップデートの内容ともども、見逃さないようにしよう。
Posted @ Wednesday, November 09, 2011 8:00 PM by アトランティカ(Atlantica) RMT
Nikeのハイエンドのサ576 ニューバランスッカーシューズのシリーズELITEある去年派手な1時、adidasは品質はNIKEに負けませんますが、しかし位置付けの上で風下に降りました。近日、1組のサッカナイキ バスケ シューズ ーシューズのスパイはによってadidasの重いサッカーシューズの王の席に帰る遠大な抱負を暴露しました。adidasはadiPOWER PREDATORが発表するこシューズ アディダスとをきっかけにするを、SLシリーズのトップクラスのサッカーシューズの製品を出して、その中はPREDATOR SLとadiPURE SLを含みました。2足の靴はすべてF50を採用しました adiZEROの軽量で大きい底、靴の表面の材質も普通な版と違い、大いに重さを軽減しました。さらに加えて再ネイティブ フィッツシモンズびサッカーシューズの軽量の王冠のF50を奪います adiZERO PRIME,adidasのトップクラスのサッカーのシリーズはすでに準備し出発を待ちました。NIKEとadidasの双雄間もなく引き離す大きい幕。 
 
Posted @ Tuesday, November 15, 2011 9:27 PM by ネイティブ フィッツシモンズ
http://www.chinaled6.com/c_html_products/leddimaideng-101.html
Posted @ Wednesday, December 21, 2011 2:22 AM by brother ink cartridge
http://www.chinaled6.com/c_html_products/leddimaideng-101.html
Posted @ Wednesday, December 21, 2011 2:32 AM by Led strip light
 有名な潮流ブランドアディダスoriginalsは今年ブーツ 人気秋に打ち出されたarchivブーツ レディースe packをつけていて、二足kopenhagenシューズと、靴の甲を采用トリーバーチ ウェッジし、高品质の紐コン部品を采用しているキャンバスベルスタッフ 
 
真鍮、靴面と内側を采用しているうえ、kopenhagen真皮材靴を独自の外形にミズノ サッカーは全体としては一種の異端児レトロ風情がある。同モデル靴姿は、今年11月ロング ムートン ブーツ、英国の运动靴の店鋪sizeだったのだろうか。店頭で、好きな友達見逃してはいけない。
Posted @ Wednesday, December 21, 2011 3:04 AM by ブーツ
http://www.google.com.hk/search?hl=en&newwindow=1&safe=active&client=aff-cs-360chromium&hs=tWF&q=Add+Comment++site%3Ahttp%3A%2F%2Fsilvermoonfox.knightshade.info&btnG=Search
Posted @ Sunday, September 09, 2012 9:24 PM by deg
Really a nice blog sir.Great information about < href="http://www.locksmithsbowie.com/crofton-maryland-locksmith.php">Locksmith bowie
Posted @ Friday, May 10, 2013 1:21 PM by Bowie MD locksmith
Amazing!I also wish him good luck to defend his gold medal. I like to share it with all my friends and hope they will also encourage him.  
limo dallas town 
Posted @ Thursday, September 12, 2013 3:17 PM by ewa
I'm still learning from you, but I try to reach my goals. Since then enjoy reading all the information that appears on your blog.Keep come. Loved it! 
Posted @ Tuesday, September 24, 2013 11:55 AM by airport cab in irving
Certainly a fantastic piece of work ... It has relevant information. Thanks for posting this. Your blog is so interesting and very informative.Thanks sharing. Definitely a great piece of work Thanks for your work. 
Posted @ Tuesday, September 24, 2013 2:15 PM by irving airport taxi
A healthy diet is not about strict nutrition philosophies, staying extremely thin, or depriving yourself of foods you love. Rather it is to get that good to have more energy and you keep healthy as possible. 
Posted @ Tuesday, September 24, 2013 3:46 PM by taxi service dallas airport
I am also interested in this topic. I have spent a lot of time on searching this kind of topic. It is very informative.  
Irving Taxi Service 
Posted @ Tuesday, September 24, 2013 4:44 PM by Irving Taxi Service
Congratulation for the great post. Those who come to read your Information will find lots of helpful and informative tips. 
Irving Taxi 
Posted @ Tuesday, September 24, 2013 4:58 PM by Irving Taxi
I am so glad this internet thing works and your Information really helped me. Might take you up on that home advice you. 
Taxi Cab in Irving 
Posted @ Tuesday, September 24, 2013 5:05 PM by Taxi Cab in Irving
I am so happy to read this. This is the kind of manual that needs to be given and not the random misinformation thats at the other blogs. Thanks for sharing this. 
Taxi Cab Dallas 
Posted @ Tuesday, September 24, 2013 5:13 PM by Taxi Cab Dallas
I am still learning from you, but I am trying to achieve my goals. I certainly enjoy reading all that is posted on your blog. Keeps the information coming. I loved it! 
Taxi in Irving Texas 
Posted @ Tuesday, September 24, 2013 5:20 PM by Taxi in Irving Texas
Really i appreciate the effort you made to share the knowledge.The topic here i found was really effective to the topic which i was researching for a long time 
buy hydrocodone online 
Posted @ Tuesday, September 24, 2013 5:20 PM by john
I am so glad this internet thing works and your Information really helped me. Might take you up on that home advice you. 
<strong>town car plano</strong> 
Posted @ Tuesday, September 24, 2013 5:37 PM by XOX
Thanks for writing the review. 
airport car service in dallas town
Posted @ Tuesday, September 24, 2013 5:37 PM by XOX
There are many things I can know only after reading your wonderful Information. 
airport car in dfw 
Posted @ Tuesday, September 24, 2013 5:38 PM by XOX
Very significant Information for us, I have think the representation of this Information is actually superb one. This is my first visit to your site. 
cheap irving taxi
Posted @ Tuesday, September 24, 2013 5:38 PM by XOX
Good info and Thanks for sharing this with us. 
buy percocet online
Posted @ Tuesday, September 24, 2013 5:39 PM by XOX
You made some good points; I did a little research on the topic and found that most people agree with your blog. Thanks.  
taxi service dallas
Posted @ Tuesday, September 24, 2013 5:39 PM by XOX
Thanks a lot for sharing this amazing knowledge with us. This site is fantastic. I always find great knowledge from it.
Posted @ Thursday, September 26, 2013 8:19 AM by local movers fairfax va
Thanks for providing such useful information. I really appreciate your professional approach.
Posted @ Thursday, September 26, 2013 8:19 AM by local movers in rockville md
Thanks for the informative writing. Would mind updating some good tips about it. I still wait your next place.
Posted @ Thursday, September 26, 2013 8:20 AM by local movers in columbia md
Thanks for your Information, I like your blog very much, Well done.
Posted @ Thursday, September 26, 2013 8:20 AM by local movers in arlington va
Thanks, I was looking for information and your blog really helped me.
Posted @ Thursday, September 26, 2013 8:21 AM by dc local movers
I wish to be a part of this concert. Thanks for writing the review.
Posted @ Friday, September 27, 2013 5:48 AM by buy best health supplements for men
My partner and I stumbled over here from a different web page and thought I might check things out. I like what I see so now i am following you. Look forward to going over your web page repeatedly.
Posted @ Friday, September 27, 2013 5:48 AM by local movers woodbridge va
The positive comments and do well wishes are very motivational and greatly appreciated.
Posted @ Tuesday, October 01, 2013 7:00 AM by local movers falls church va
Hats off to you! The information that you have provided is very helpful.
Posted @ Tuesday, October 01, 2013 7:08 AM by local movers Gaithersburg MD
I was always in search of such useful information you have shared in this blog. This will help me in my working.
Posted @ Tuesday, October 01, 2013 7:20 AM by local movers Frederick MD
Hello Dear, Really your blog is very interesting.... it contains great and unique information. I enjoyed to visiting your blog. It's just amazing.... Thanks very much.
Posted @ Tuesday, October 01, 2013 7:56 AM by local movers in washington dc
I just want to thank you for sharing your information and your site or blog this is simple but nice Information I’ve ever seen i like it i learn something today.
Posted @ Tuesday, October 01, 2013 8:08 AM by local movers wheaton md
Simple, useful and very Interesting Post. Keep it up.
Posted @ Tuesday, October 01, 2013 8:14 AM by local movers jessup md
Thanks for the great post. You have a well written and informative blog especially for us.
Posted @ Tuesday, October 01, 2013 9:03 AM by locksmith washington dc
Hello, an amazing Information dude. Thanks for sharing this nice information with us.
Posted @ Tuesday, October 01, 2013 9:20 AM by locksmith bethesda md
Thank you, I have recently been searching for information about this topic for ages and yours is the best I have discovered so far.
Posted @ Tuesday, October 01, 2013 9:36 AM by locksmith dc
Really good website this is, full of useful information and advice. Thanks for sharing.
Posted @ Tuesday, October 01, 2013 9:52 AM by local movers dickerson md
Thanks for the great post. You have a well written and informative blog especially for us.
Posted @ Tuesday, October 01, 2013 10:00 AM by local movers eldersburg md
Great Information, very interesting and useful for me. Thanks!
Posted @ Tuesday, October 01, 2013 10:53 AM by dc locksmith
Thank you, I have recently been searching for information about this topic for ages and yours is the best I have discovered so far.
Posted @ Tuesday, October 01, 2013 11:06 AM by local movers lisbon md
I enjoy a couple of from the Information which has been written, and particularly the comments posted! I will definitely be visiting again!
Posted @ Wednesday, October 02, 2013 4:50 AM by local movers in alexandria va
I am really enjoying reading your well written Information. I think you spend numerous effort and time updating your blog. I have bookmarked it and I am taking a look ahead to reading new Information. Please keep up the good Information!
Posted @ Wednesday, October 02, 2013 5:25 AM by local movers college park md
This was a really outstanding post. In theory I would like to compose like this too - taking time and real effort to make solid Information.
Posted @ Wednesday, October 02, 2013 7:08 AM by buy online anti aging supplements
Hey your collection is outstanding; I never see such a type of collection before. Thanks for sharing it with us. Keep it up.
Posted @ Wednesday, October 02, 2013 7:16 AM by buy online anti aging supplements
I already saw many blogs but I like this commenting platform. Thanks a lot for your guidance and sharing information.
Posted @ Wednesday, October 02, 2013 7:17 AM by buy online bath beauty products
Very interesting thanks. I believe there's even more that could be on there! Keep it up.
Posted @ Friday, November 01, 2013 10:50 AM by pure naturals
Wow.. it’s a great place to get information ... Because now a days any kind of little bit information is every helpful.. Wonderful Information.
Posted @ Friday, November 01, 2013 10:52 AM by wholesale health products
Post Comment
Name
 *
Email
 *
Website (optional)
Comment
 *

Allowed tags: <a> link, <b> bold, <i> italics